Pragmatic and mechanistic trials
نویسندگان
چکیده
منابع مشابه
A pragmatic view on pragmatic trials
Clinical trials have been the main tool used by the health sciences community to test and evaluate interventions, Trials can fall into two broad categories: pragmatic and explanatory. Pragmatic trials are designed to evaluate the effectiveness of interventions in real-life routine practice conditions, whereas explanatory trials aim to test whether an intervention works under optimal situations....
متن کاملLimitations of "pragmatic" trials.
C linical trials testing the value of therapeutic interventions range between the two extremes of maximal internal or external validity. The former study, often called an efficacy trial, tests a treatment under optimal (that is, near laboratory) conditions, in which features such as the patient sample, the intervention, and the outcome measures are narrowly defined. Their research question is u...
متن کاملA Pragmatic-Ontic Account of Mechanistic Explanation
Craver‟s (2007) account of explanation in neurobiology offers one of the most sophisticated explications of the mechanism concept. This paper argues that despite groundbreaking advances in understanding mechanistic explanation, serious challenges remain. The first goal of this paper is to address the notorious problem of explanatory relevance concerning mechanistic explanation. I argue that Cra...
متن کامل'Pragmatic' and 'explanatory' attitudes to randomised trials.
In the early days of randomised control trials the ability to reduce confounding fromknownand unknown confounders rightly underpinned their rapid rise in methodological popularity. Ever since, however, concerns have been expressed by the clinician community and others about the difficulty of applying estimates of effects derived from randomised control trials to settings and patient populations...
متن کاملExplanatory and pragmatic attitudes in therapeutical trials.
It is the thesis of this paper that most therapeutic trials are inadequately formulated, and this from the earliest stages of their conception. Their inadequacy is basic, in that the trials may be aimed at the solution of one or other of two radically different kinds of problem; the resulting ambiguity affects the definition of the treatments, the assessment of the results, the choice of subjec...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 1997
ISSN: 0195-668X,1522-9645
DOI: 10.1093/oxfordjournals.eurheartj.a015256